[Autoimmunity].
نویسنده
چکیده
Autoimmune diseases comprise a large, diverse group of diseases characterized by a humoral or cell-mediated immune response against the constituents of the body's own tissues. In cases in which the host is sensitized with a tissue-specific antigen, a single pathological immune reaction occurs in the target organ. In those cases in which the host is sensitized with either a single tissue nonspecific or many tissue-specific antigens, several pathological immune reactions occur in many target organs. Examples bf each type of autoimmune disease are shown in Tables 1 and 2. This classification is arbitrary, and in certain patients a combination of immunological reactions may be detected. Furthermore, what is considered organ-specific presently may turn out to be multiorgan diseases in the future. Within the organ-specific autoimmune diseases, there is a group (Table 3) of diseases in which the patients produce autoantibodies directed against different cell surface receptors.'"^ Autoantibodies will bind these cell surface receptors and impair their physiologic function. The common feature to all these diseases is the crosslinking of cell surface receptors, which occurs after binding the autoantibody.^ Moreover, this immunological reaction increases the metabolic degradation of these receptors. Abnormal receptor function may result from receptor blockade or decrease in the number of receptors available due to increased degradation of these molecules. In some cases, the autoantibody has been
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عنوان ژورنال:
- Soins; la revue de reference infirmiere
دوره 507 شماره
صفحات -
تاریخ انتشار 1978